NMRAL1 Products

Description

Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes inintracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and bindsargininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs itsactivity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPHconcentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one moleculeof NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer

Bioinformatics

Uniprot	Q9HBL8 Human NM_020677 Human NP_065728 Human NP_065728.1 Human
Product By Gene ID	57407
Alternate Names	short chain dehydrogenase/reductase family 48A, member 1 nmrA-like family domain-containing protein 1 SDR48A1 HSCARGFLJ25918 NmrA-like family domain containing 1

Diseases related to NMRAL1

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Malignant Neoplasms

Pathways for NMRAL1

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Mrna Transcription
Proteolysis
Cell Growth
Nuclear Export

PTMs for NMRAL1

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Phosphorylation
Ubiquitination

Bioinformatics Tool for NMRAL1

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