NMDAR2A Antibody (S327-95) [FITC]

• Reactivity: Hu, Mu, Rt
• Applications: ICC/IF, IHC
• Clone: S327-95
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: FITC

NMDAR2A Antibody (S327-95) [FITC] Summary

• Immunogen: Fusion protein amino acids 75-325 (extracellular N-terminus) of rat GluN2A/NR2A
• Localization: Cell Membrane , Cell Junction
• Specificity: Detects approx 170kDa. Does not react with NR2B.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: GRIN2A
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for NMDAR2A Antibody (S327-95) [FITC]

• GluN2A
• glutamate receptor, ionotropic, N-methyl D-aspartate 2A
• hNR2A
• NMDA receptor subtype 2A
• N-methyl D-aspartate receptor subtype 2A
• N-methyl-D-aspartate receptor subunit 2A
• subunit epsilon-1

Background

The ion channels activated by glutamate are divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). NMDA receptors are among the most studied receptors in neuroscience because they are involved in neuronal cell development and plasticity, a cellular correlate for learning. NMDA receptors are also implicated in several disorders of the central nervous system including epilepsy and ischemic neuronal cell death. NMDA receptors also appear to be a target for ethanol at physiological concentrations and therefore may play a significant role in alcoholism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GRIN2A