NK1R Antibody (694501) [Phycoerythrin]

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HEK293 human embryonic kidney cell line transfected with (A) human NK1R or (B) irrelevant protein, and eGFP was stained with Mouse Anti-Human NK1R PE-conjugated Monoclonal Antibody (Catalog # FAB66871P) or Mouse IgG3 ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
694501
Clonality
Monoclonal
Host
Mouse
Conjugate
Phycoerythrin

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Catalog# & Conjugate Size Price
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NK1R Antibody (694501) [Phycoerythrin] Summary

Immunogen
HEK293 human embryonic kidney cell line transfected with human NK1R
Accession # P25103
Specificity
Detects human NK1R in ELISAs.
Source
N/A
Isotype
IgG3
Clonality
Monoclonal
Host
Mouse
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NK1R Antibody (694501) [Phycoerythrin]

  • NK1R
  • NK-1R
  • NK1Rneurokinin 1 receptor
  • NKIR
  • SPR
  • SPRsubstance-P receptor
  • TAC1R
  • TAC1Rtachykinin 1 receptor (substance P receptor, neurokinin 1 receptor)
  • tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
  • tachykinin receptor 1NK-1 receptor
  • TACR1

Background

NK1R (Neurokinin-1 receptor), gene name TACR1 (tachykinin receptor-1), is an ~80 kDa 7-transmembrane glycoprotein receptor for the proinflammatory tachykinin neuropeptide, substance P. NK1R is constitutively or inducibly expressed on a wide variety of cells, including monocytes, macrophages, microglia, lymphocytes, neutrophils, mast cells, and neurons. The 407 amino acid (aa) human NK1R contains 89 extracellular aa over multiple segments which collectively share 92% aa identity with corresponding regions of mouse and rat NK1R. A ~50 kDa short isoform that ends at aa 311 lacks almost all of the C-terminal cytoplasmic signaling region. It is the only form expressed in human monocytes and undifferentiated THP-1 cells, and its function appears to differ from the long isoform.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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