Niemann-Pick type C2 Antibody (1F4)

Immunoprecipitation: Niemann-Pick type C2 Antibody (1F4) [H00010577-M11] - Analysis of NPC2 transfected lysate using anti-NPC2 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with NPC2 rabbit polyclonal antibody.

ELISA: Niemann-Pick type C2 Antibody (1F4) [H00010577-M11] - Detection limit for recombinant GST tagged NPC2 is 0.03 ng/ml as a capture antibody.

Product Discontinued

Niemann-Pick type C2 Antibody (1F4) Summary

• Immunogen: NPC2 (NP_006423.1, 52 a.a. ~ 151 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. GQSYSVNVTFTSNIQSKSSKAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYSYLNKLPVKSEYPSIKLVVEWQLQDDKNQSLFCWEIPVQIVSHL
• Specificity: Reacts with Niemann-Pick disease, type C2.
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: NPC2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoprecipitation
• Application Notes: This antibody is reactive against recombinant protein in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Niemann-Pick type C2 Antibody (1F4)

• EDDM1
• Epididymal Protein 1
• epididymal secretory protein E1
• HE1
• HE1epididymal protein 1
• Human epididymis-specific protein 1
• MGC1333
• Niemann-Pick disease type C2 protein
• Niemann-Pick disease, type C2
• NiemannPick Type C2
• Niemann-Pick Type C2
• NPC2
• NP-C2
• tissue-specific secretory protein

Background

This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Niemann-Pick type C2 Antibody (H00010577-M11). (Showing 1 - 1 of 1 FAQ).

1. I'm looking for a Niemann-Pick type1 or 2 antibody to stain mouse heart section embedded in paraffin. I would like to label these sections with another primary antibody to show colocalisation of my protein of interest. I would like to know if you have a rabbit anti-Niemann-Pick antibody that works well for fluorescence immunohistochemistry?
   • Niemann-Pick C1 Antibody (NB400-148) (0.1 ml) is one of our best sellers and this antibody has been cited in at least 17 peer reviewed research publications in journals of high repute. We have only one Niemann-Pick type C2 antibody with catalog # H00010577-D01PInnovators Reward Program.

Bioinformatics

• Gene Symbol: NPC2
• Entrez:
  • 10577(Human)
• Uniprot:
  • NP_006423(Human)