NFKBIL2 Antibody (648) [Biotin]

Product Discontinued

NFKBIL2 Antibody (648) [Biotin] Summary

• Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human NFKBIL2. The exact sequence is proprietary.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TONSL
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Mouse (83%), Rat (82%).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for NFKBIL2 Antibody (648) [Biotin]

• IkappaBR
• I-kappa-B-related protein
• IKBRFLJ40087
• Inhibitor of kappa B-related protein
• NF-kappa-B inhibitor-like protein 2
• NFKBIL2tonsoku-like protein
• Nuclear factor of kappa light polypeptide gene enhancer in B-cellsinhibitor-like 2ikappaBR
• tonsoku-like, DNA repair protein

Background

Sharing some sequence similarities with IKBKB, NF-kappa-B inhibitor-like protein 2 (NFKBIL2) belongs to the Tonsoku family. Also known as TONSL, the protein encoded by this gene may bind NF-kappa-B complex and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Additionally, NFKBIL2 is a component of the MMS22L-TONSL complex. Used during DNA replication, this complex is essential for promoting homologous recombination repair of replication fork double strand breaks. NFKBIL2 is known to interact with MMS22L, MCM4, SSRP1, GSK3B and MCM2. Diseases associated with this gene include t-cell leukemia, psoriasis, breast cancer, atherosclerosis, leukemia and immunodeficiency.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TONSL