NFKBIL2 Products

Description

Sharing some sequence similarities with IKBKB, NF-kappa-B inhibitor-like protein 2 (NFKBIL2) belongs to the Tonsoku family. Also known as TONSL, the protein encoded by this gene may bind NF-kappa-B complex and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Additionally, NFKBIL2 is a component of the MMS22L-TONSL complex. Used during DNA replication, this complex is essential for promoting homologous recombination repair of replication fork double strand breaks. NFKBIL2 is known to interact with MMS22L, MCM4, SSRP1, GSK3B and MCM2. Diseases associated with this gene include t-cell leukemia, psoriasis, breast cancer, atherosclerosis, leukemia and immunodeficiency.

Bioinformatics

Uniprot	AAH08782.1 Human Q96HA7 Human NP_038460 Human
Product By Gene ID	4796
Alternate Names	I-kappa-B-related protein IkappaBR Inhibitor of kappa B-related protein NFKBIL2tonsoku-like protein Nuclear factor of kappa light polypeptide gene enhancer in B-cellsinhibitor-like 2ikappaBR IKBRFLJ40087 NF-kappa-B inhibitor-like protein 2 tonsoku-like, DNA repair protein

Diseases related to NFKBIL2

Discover more about diseases related to NFKBIL2.

Genomic Instability
Physiological Stress
Inflammation
Acquired Immunodeficiency Syndrome
Ischemia
Emotional Distress
Inflammatory Bowel Diseases
Inflammatory Response
Pneumococcal Infections
Pneumonia
Immunologic Deficiency Syndromes
Systemic Infection
Hemorrhage
Primary Immune Deficiency Disorder
Bacteremia
Asthma
Pneumococcal Sepsis
Infectious Canine Hepatitis
Crohn Disease
Cerebral Hemorrhage

Pathways for NFKBIL2

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Dna Replication
Proteolysis
Cell Death
Nuclear Migration
Dna Damage Checkpoint
S Phase
Immune Response
Hypersensitivity
Pathogenesis
Localization
Double-strand Break Repair
Inflammatory Response

PTMs for NFKBIL2

Learn more about PTMs related to NFKBIL2.

Phosphorylation

Bioinformatics Tool for NFKBIL2

Discover related pathways, diseases and genes to NFKBIL2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.