NFKBIL2 Products

Description

Sharing some sequence similarities with IKBKB, NF-kappa-B inhibitor-like protein 2 (NFKBIL2) belongs to the Tonsoku family. Also known as TONSL, the protein encoded by this gene may bind NF-kappa-B complex and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Additionally, NFKBIL2 is a component of the MMS22L-TONSL complex. Used during DNA replication, this complex is essential for promoting homologous recombination repair of replication fork double strand breaks. NFKBIL2 is known to interact with MMS22L, MCM4, SSRP1, GSK3B and MCM2. Diseases associated with this gene include t-cell leukemia, psoriasis, breast cancer, atherosclerosis, leukemia and immunodeficiency.

Bioinformatics

Uniprot	AAH08782.1 Human NP_038460 Human Q96HA7 Human
Product By Gene ID	4796
Alternate Names	IkappaBR I-kappa-B-related protein IKBRFLJ40087 Inhibitor of kappa B-related protein NF-kappa-B inhibitor-like protein 2 NFKBIL2tonsoku-like protein Nuclear factor of kappa light polypeptide gene enhancer in B-cellsinhibitor-like 2ikappaBR tonsoku-like, DNA repair protein