NFATC4 Antibody

Product Discontinued

NFATC4 Antibody Summary

• Immunogen: Peptide with sequence C-EATVNRLQSNEVTLT corresponding to internal region according to NP_001129494.1, NP_004545.2.
• Epitope: internal region
• Specificity: This antibody is expected to recognize both isoforms (NP_001129494.1; NP_004545.2).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NFATC4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:64000
• Application Notes: WB: Preliminary experiments in human heart, Jurkat and MOLT-4 lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for NFATC4 Antibody

• NF-AT3
• NFAT3nuclear factor of activated T-cells, cytoplasmic 4
• NFATc4
• NF-ATc4
• nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
• T cell transcription factor NFAT3
• T-cell transcription factor NFAT3

Background

NFATC4 is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a pre-existing cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NFATC4 Antibody (NBP1-36747)(1)

Publication using NBP1-36747

• Yao K, Cho YY, Bergen HR et al. Nuclear factor of activated T3 is a negative regulator of Ras-JNK1/2-AP-1 induced cell transformation. Cancer Res 2007-01-01 [PMID: 17875713]

Bioinformatics

• Gene Symbol: NFATC4
• Entrez:
  • 4776(Human)
• Uniprot:
  • NP_001129494.1(Human)