NF2/Merlin Antibody

Images

 
Western Blot: NF2/Merlin Antibody [NBP1-33531] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 C: Hela 7.5% SDS PAGE diluted at 1:1000
Immunohistochemistry-Paraffin: NF2/Merlin Antibody [NBP1-33531] - Paraffin-embedded Gastric ca, using antibody at 1:500 dilution.
Western Blot: NF2/Merlin Antibody [NBP1-33531] - Sample (20 ug of whole cell lysate) A: mouse brain 7.5% SDS PAGE diluted at 1:10000
Immunohistochemistry-Paraffin: NF2/Merlin Antibody [NBP1-33531] - Paraffin-embedded RT2 xenograft, using Neurofibromin 2 antibody at 1:500 dilution.

Product Details

Summary
Reactivity Hu, Mu, Rt, Ch, RM, XpSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

NF2/Merlin Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Neurofibromin 2. The exact sequence is proprietary.
Localization
Isoform 1: Cell projection, filopodium membrane, Peripheral membrane protein, Cytoplasmic side, Cell projection, ruffle membrane, Peripheral membrane protein, Cytoplasmic side, Isoform 7: Cytoplasm, perinuclear region, Cytoplasmic granule, Isoform
Predicted Species
Rhesus Macaque (97%), Chicken (95%), Xenopus (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NF2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000-1:10000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control
NF2/Merlin Lysate (NBP2-65209)

Reactivity Notes

Xenopus laevis (92%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol
Preservative
0.01% Thimerosal
Purity
Immunogen affinity purified

Alternate Names for NF2/Merlin Antibody

  • ACN
  • BANF
  • Merlin
  • moesin-ezrin-radixin like
  • Moesin-ezrin-radixin-like protein
  • moesin-ezrin-radizin-like protein
  • neurofibromin 2 (bilateral acoustic neuroma)
  • neurofibromin 2 (merlin)
  • neurofibromin-2
  • NF2
  • SCH
  • Schwannomerlin
  • Schwannomin

Background

Neurofibromin 2 (NF2) is a tumor suppressor gene encoding the protein Merlin. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise funtion of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. It has been implicated in cell proliferation and cellular motility. Mutations in the NF2 gene cause neurofibromatosis type II, a condition characterised by the development of tumors in the central nervous system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol NF2
Entrez
Uniprot