NF2/Merlin Antibody [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB, IHC, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Janelia Fluor 669

NF2/Merlin Antibody [Janelia Fluor® 669] Summary

• Immunogen: E. coli-derived recombinant human NF2
  Met363-Lys578
  Accession # P35240
• Specificity: Detects human NF2 in Western blots and direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NF2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for NF2/Merlin Antibody [Janelia Fluor® 669]

• ACN
• BANF
• Merlin
• moesin-ezrin-radixin like
• Moesin-ezrin-radixin-like protein
• moesin-ezrin-radizin-like protein
• neurofibromin 2 (bilateral acoustic neuroma)
• neurofibromin 2 (merlin)
• neurofibromin-2
• NF2
• SCH
• Schwannomerlin
• Schwannomin

Background

Merlin, also known as Neurofibromin 2 (NF2), is a tumor suppressor gene. Merlin is closely related to the ERM (ezrin, radixin, moesin) family of proteins. The precise function of Merlin is not clear. It is thought to provide a link between the actin cytoskeleten and membrane associated proteins, playing a role in transduction of extracellular signals. Merlin has been implicated in cell proliferation and cellular motility.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NF2