Neurexin 3/NRXN3 Antibody

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Product Details

Summary
Reactivity Hu, Mu, Po, CaSpecies Glossary
Applications PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Neurexin 3/NRXN3 Antibody Summary

Immunogen
Peptide with sequence C-PQERKDARSQKNT corresponding to internal region according to NP_004787.2.
Epitope
C terminus
Specificity
This antibody is expected to recognize the reported isoform 1 (NP_004787.2).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
NRXN3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Peptide ELISA Detection limit 1:4000
Application Notes
WB: Preliminary experiments gave an approx. 24 kDa band in human brain (cerebellum) lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 117 kDa band according to NP_004787.2. The 24 kDa band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-28485.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
Tris (pH 7.3), 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Neurexin 3/NRXN3 Antibody

  • C14orf60
  • chromosome 14 open reading frame 60
  • KIAA0743MGC176711
  • Neurexin 3
  • neurexin III
  • Neurexin III-alpha
  • Neurexin III-beta
  • neurexin-3-beta
  • NRXN3

Background

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Neurexin 3/NRXN3 Antibody (NBP1-28485)(1)

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Bioinformatics

Gene Symbol NRXN3
Entrez
Uniprot