NEDP1/SENP8 Antibody [CoraFluor™ 1]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: CoraFluor 1

NEDP1/SENP8 Antibody [CoraFluor™ 1] Summary

• Immunogen: E. coli-derived recombinant human NEDP1/SENP8
  Met1-Lys212 (Thr207Ala)
  Accession # Q96LD8
• Specificity: Detects human, mouse, rat NEDP1/SENP8 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: SENP8
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for NEDP1/SENP8 Antibody [CoraFluor™ 1]

• DEN1
• DEN1deneddylase-1
• deneddylase 1
• Deneddylase-1
• EC 3.4.22.-
• HsT17512
• NEDD8-specific protease 1
• NEDP1
• NEDP1NEDD8 specific-protease cysteine 2
• Protease, cysteine 2
• protease, cysteine, 2 (NEDD8 specific)
• PRSC2
• SENP8
• Sentrin/SUMO-specific protease SENP8
• sentrin-specific protease 8
• SUMO sentrin specific protease family member 8
• SUMO/sentrin specific peptidase family member 8
• SUMO/sentrin specific protease family member 8

Background

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003 [PubMed 12759363]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SENP8