NEDP1/SENP8 Products

Description

NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003 [PubMed 12759363]).[supplied by OMIM]

Bioinformatics

Entrez	123228 Human 71599 Mouse 315723 Rat
Uniprot	NM_145204 Human NP_660205 Human Q96LD8 Human NP_001159812 Human
Product By Gene ID	123228
Alternate Names	SUMO/sentrin specific protease family member 8 Sentrin/SUMO-specific protease SENP8 protease, cysteine, 2 (NEDD8 specific) EC 3.4.22.- HsT17512 Deneddylase-1 NEDD8-specific protease 1 SUMO sentrin specific protease family member 8 PRSC2 sentrin-specific protease 8 Protease, cysteine 2 NEDP1NEDD8 specific-protease cysteine 2 DEN1deneddylase-1 deneddylase 1 SUMO/sentrin specific peptidase family member 8

Diseases related to NEDP1/SENP8

Discover more about diseases related to NEDP1/SENP8.

Neoplasms
Leukoencephalopathy, Progressive Multifocal
Cell Transformation, Neoplastic
Malnutrition
Inflammatory Response
Osteosarcoma
Malignant Neoplasms
Prostatic Neoplasms
Leukemia
Acute Promyelocytic Leukemia
Inflammation
Mammary Neoplasms
Trematode Infections

Pathways for NEDP1/SENP8

View related products by pathway and learn more about each of the pathways below.

Conjugation
Proteolysis
Cell Cycle
Transport
Cell Proliferation
Cytokine Secretion
Localization
Nuclear Transport
Inflammatory Response
Cell Death
Regulation Of Cell Proliferation
Autophagy
Secretion

PTMs for NEDP1/SENP8

Learn more about PTMs related to NEDP1/SENP8.

Cleavage
Ubiquitination

Bioinformatics Tool for NEDP1/SENP8

Discover related pathways, diseases and genes to NEDP1/SENP8. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.