Species: Hu, Mu, Rt
Applications: WB
Host: Sheep Polyclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the cullin (see CUL1; MIM 603134) subunit of several ubiquitin ligases. This conjugation, called neddylation, is required for optimal ubiquitin ligase activity. NEDD8-specific deneddylases, such as NEDP1, or DEN1, are required to process the NEDD8 propeptide at a C-terminal diglycine motif and to remove NEDD8 from cullins (Gan-Erdene et al., 2003 [PubMed 12759363]).[supplied by OMIM]
Bioinformatics
| Entrez |
Human
Rat
Mouse
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
123228 |
| Alternate Names |
- DEN1deneddylase-1
- deneddylase 1
- Deneddylase-1
- EC 3.4.22.-
- HsT17512
- NEDD8-specific protease 1
- NEDP1NEDD8 specific-protease cysteine 2
- Protease, cysteine 2
- protease, cysteine, 2 (NEDD8 specific)
- PRSC2
- Sentrin/SUMO-specific protease SENP8
- sentrin-specific protease 8
- SUMO sentrin specific protease family member 8
- SUMO/sentrin specific peptidase family member 8
- SUMO/sentrin specific protease family member 8
|
