NAALADase-2/NAALAD2 Antibody (756030) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 756030
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

NAALADase-2/NAALAD2 Antibody (756030) [Alexa Fluor® 700] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human NAALADase-2/NAALAD2
  Lys32-Leu740
  Accession # Q9Y3Q0
• Specificity: Detects human NAALADase-2/NAALAD2 in direct ELISAs. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse NAALADase-2 is observed and no cross-reactivity with recombinant human (rh) PSMA/FOLH1/NAALADase-1, rhNAALADase-like 2, or rh
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NAALADase-2/NAALAD2 Antibody (756030) [Alexa Fluor® 700]

• GCPIII
• Glutamate Carboxypeptidase III
• GPCIII
• MGC116996
• MGC26353
• NAADALASE2
• NAALAD2
• NAALADase II
• NAALADase2
• NAALADase-2
• N-acetylated alpha-linked acidic dipeptidase 2
• N-acetylated alpha-linked acidic dipeptidase II
• N-acetylated-alpha-linked acidic dipeptidase 2
• N-acetylated-alpha-linked acidic dipeptidase II

Background

N-acetylated-alpha-linked acidic dipeptidase 2 (NAALADase-2), also known as glutamate carboxypeptidase 3 (GCP3), is a 90-100 kDa type 2 transmembrane protein in the M28 peptidase family. It hydrolyzes beta-citrylglutamate (BCG) and N-acetyl-aspartylglutamate (NAAG) which are abundant dipeptides found in brain and testis. Mature human NAALADase-2 consists of a 7 amino acid (aa) cytoplasmic domain, a 24 aa transmembrane segment, and a 709 aa extracellular region (aa 32-740) that contains the peptidase domain. Over aa 32-740, human NAALADase-2 shares 89% aa sequence identity with mouse NAALADase-2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.