Mus81 Antibody

Product Discontinued

Mus81 Antibody Summary

• Immunogen: Recombinant protein encompassing a sequence within the center region of human MUS81. The exact sequence is proprietary.
• Localization: Nucleus , nucleolus
• Predicted Species: Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MUS81
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:100-1:1000
  • Western Blot 1:500-1:3000
• Theoretical MW: 61 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Chimpanzee (99%).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.0) and 40% Glycerol
• Preservative: 0.01% Thimerosal
• Purity: Protein A purified

Alternate Names for Mus81 Antibody

• crossover junction endonuclease MUS81
• EC 3.1.22
• EC 3.1.22.-
• FLJ21012
• FLJ44872
• MUS81 endonuclease homolog (S. cerevisiae)
• MUS81 endonuclease homolog (yeast)
• SLX3 structure-specific endonuclease subunit homolog
• SLX3

Background

Mus81 and EME1 constitute a heterodimeric endonuclease that has been implicated in mitotic and meiotic recombination in eukaryotes. Reduction or loss of a protein called Mus81 can led to the development of lymphomas and other tumours in mice. Mus81 is a protein long thought to be involved in repairing DNA that is damaged during normal metabolic processes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Publications for Mus81 Antibody (NBP1-32054)(1)

Publication using NBP1-32054

• Sun X, Brieno-Enriquez MA, Cornelius A et al. FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice. Chromosoma. 2015-10-21 [PMID: 26490168] (WB, Mouse)

Bioinformatics

• Gene Symbol: MUS81