MTGR1 Antibody

Western Blot: MTGR1 Antibody [H00009139-B01P] - Analysis of CBFA2T2 expression in human colon.

Immunocytochemistry/Immunofluorescence: MTGR1 Antibody [H00009139-B01P] - Analysis of purified antibody to CBFA2T2 on HeLa cell. (antibody concentration 10 ug/ml)

Western Blot: MTGR1 Antibody [H00009139-B01P] - Analysis of CBFA2T2 expression in transfected 293T cell line by CBFA2T2 polyclonal antibody. Lane 1: CBFA2T2 transfected lysate(63.25 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

MTGR1 Antibody Summary

• Immunogen: CBFA2T2 (NP_001034798.1, 1 a.a. - 575 a.a.) full-length human protein. MPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVGRGSSARSADCSVPSPALDKTSATTSRSSTPASVTAIDTNGL
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: CBFA2T2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: This antibody is useful for Western Blot, Immunofluorescence

Reactivity Notes

This product is reactive against Human.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MTGR1 Antibody

• core-binding factor, runt domain, alpha subunit 2; translocated to, 2
• EHTDKFZp313F2116
• ETO homolog on chromosome 20
• ETO homologous on chromosome 20
• MTG8-like protein
• MTG8-related protein 1
• MTGR1p85
• myeloid translocation gene-related protein 1
• Myeloid translocation-related protein 1
• protein CBFA2T2
• ZMYND3

Background

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CBFA2T2
• Uniprot:
  • NP_001034798.1(Human)