MTGR1 Products

Description

In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Bioinformatics

Entrez	9139 Human
Uniprot	AAH40344 Human NM_001039709 Human NP_001028171 Human NP_001028171.1 Human NP_001034798.1 Human
Product By Gene ID	9139
Alternate Names	core-binding factor, runt domain, alpha subunit 2; translocated to, 2 EHTDKFZp313F2116 ETO homolog on chromosome 20 ETO homologous on chromosome 20 MTG8-like protein MTG8-related protein 1 MTGR1p85 myeloid translocation gene-related protein 1 Myeloid translocation-related protein 1 protein CBFA2T2 ZMYND3

Research Areas for MTGR1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Tumor Suppressors