MSP/MST1 alpha Chain Antibody (45904) [Unconjugated] - a Chain

352-MS) was serially diluted and captured by Mouse Anti-Human MSP/MST1 alpha Chain Monoclonal Antibody (Catalog # MAB352) coated on a Clear Polystyrene Microplate (Catalog # DY990). Mouse Anti-Human MSP/MST1 beta Chain Monoclonal Antibody (Catalog # MAB735) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998)" > 352-MS) was serially diluted and captured by Mouse Anti-Human MSP/MST1 alpha Chain Monoclonal Antibody (Catalog # MAB352) coated on a Clear Polystyrene Microplate (Catalog # DY990). Mouse Anti-Human MSP/MST1 beta Chain Monoclonal Antibody (Catalog # MAB735) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998)" title="Recombinant Human MSP/MST1 (Catalog # 352-MS) was serially diluted and captured by Mouse Anti-Human MSP/MST1 alpha Chain Monoclonal Antibody (Catalog # MAB352) coated on a Clear Polystyrene Microplate (Catalog # DY990). Mouse Anti-Human MSP/MST1 beta Chain Monoclonal Antibody (Catalog # MAB735) was biotinylated and incubated with the protein captured on the plate. Detection of the standard curve was achieved by incubating Streptavidin-HRP (Catalog # DY998)" />

Recombinant Human MSP/MST1 (Catalog # <a class=

• Reactivity: Hu
• Applications: WB, AP, ELISA(Cap)
• Clone: 45904
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

MSP/MST1 alpha Chain Antibody (45904) [Unconjugated] - a Chain Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human MSP
  Met1-Gly711
  Accession # AAA59872
• Specificity: Detects human MSP alpha Chain in ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) HGF or rhIL‑6 is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: MST1
• Purity Statement: Protein A or G purified from ascites

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
  • ELISA Detection (Matched Antibody Pair) 0.5-2.0 ug/mL
  • ELISA Standard (Matched Pair)
  • Immunoaffinity Purification
  • Western Blot 1 ug/mL
• Application Notes: ELISA Detection: Human MSP/MST1 beta Chain Biotinylated Antibody (Catalog number BAM3521)
  Standard: Recombinant Human MSP/MST1 (Catalog number 352-MS)

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MSP/MST1 alpha Chain Antibody (45904) [Unconjugated] - a Chain

• MSP/MST1 alpha Chain

Background

MSP, also known as hepatocyte growth factor-like protein (HGFl), and scatter factor-2 (SF2), is a member of the HGF family of growth factors. It is secreted as a single chain inactive precursor which is proteolytically activated to yield a biologically active disulfide-linked heterodimer of the alpha and beta chains. MSP induces keratinocyte proliferation, bone resorption, and cell migration and shape change in resident macrophages. Heterodimeric MSP binds to and activates the cell surface receptor tyrosine kinase, RON/STK, which is expressed on mature macrophages, keratinocytes, and vascular endothelium of wounded skin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MSP/MST1 alpha Chain Antibody (MAB352)(4)

Publications using MAB352

• Viventi S, Frausin S, Howden SE et al. In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia Stem cells translational medicine 3/18/2021 [PMID: 33734599]
• HIV?1 downregulates the expression and phosphorylation of receptor tyrosine kinase by targeting the NF??B pathway Mol Med Rep, 2016-07-08;0(0):. 2016-07-08 [PMID: 27432185] (ELISA Development (Capture), Human)
• Kauder , Steven E, Santell , Lydia, Mai , Elaine, Wright , Lilyan Y, Luis , Elizabet, N'Diaye , Elsa N, Lutman , Jeff, Ratti , Navneet, Sa , Susan M, Maun , Henry R, Stefanich , Eric, Gonzalez , Lino C, Graham , Robert R, Diehl , Lauri, Faubion , William, Keir , Mary E, Young , Judy, Chaudhuri , Amitabha, Lazarus , Robert A, Egen , Jackson Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele. PLoS ONE, 2013-12-23;8(12):e83958. 2013-12-23 [PMID: 24409221] (ELISA Development, Human)
• Kerrington R. Molhoek, Amber L. Shada, Mark Smolkin, Sudhir Chowbina, Jason Papin, David L. Brautigan et al. Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R Melanoma Research 2011-08-01 [PMID: 21654344]

Bioinformatics

• Gene Symbol: MST1
• Uniprot:
  • AAA59872(Human)