MSH2 Antibody

Product Discontinued

MSH2 Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MSH2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation 1-4 ug/mg of lysate
  • Radioimmunoassay
  • Western Blot 1:500-1:5000
• Control:

  MSH2 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.1% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for MSH2 Antibody

• COCA1
• DNA mismatch repair protein Msh2
• FCC1
• hMSH2
• HNPCC
• HNPCC1
• HNPCC1mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
• LCFS2
• MSH2
• mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
• MutS protein homolog 2

Background

MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC). Alternate names for MSH2 include DNA mismatch repair protein Msh2, MutS protein homolog 2, MSH2, FCC1, COCA1, HNPCC, and HNPCC1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MSH2 Antibody (NB100-198)(1)

Publication using NB100-198

• Wang Y, Qin J. MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation. Proc Natl Acad Sci U S A 2003-12-01 [PMID: 14657349]

Bioinformatics

• Gene Symbol: MSH2
• Entrez:
  • 4436(Human)
• Uniprot:
  • P43246(Human)