Mouse IL-28B/IFN-lambda 3 DuoSet

Product Discontinued

Mouse IL-28B/IFN-lambda 3 DuoSet Summary

• Source: N/A
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details

Applications/Dilutions

• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-28B/IFN-lambda 3 DuoSet

• IFNl2
• IFNlambda 2
• IL28A
• IL-28A
• IL-28A/B (IFN-lambda 2/3)
• IL28B
• interferon lambda 2

Background

Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.

Publications for IL-28A/B (IFN-lambda 2/3) (DY1789)(17)

Publications using DY1789

• M Le Roux, A Ollivier, G Kervoaze, T Beke, L Gillet, M Pichavant, P Gosset IL-20 Cytokines Are Involved in Epithelial Lesions Associated with Virus-Induced COPD Exacerbation in Mice Biomedicines, 2021-12-05;9(12):. 2021-12-05 [PMID: 34944654] (Mouse)
• HE Rich, D Antos, CC McCourt, WQ Zheng, LJ Devito, KJ McHugh, R Gopal, J Wang, JF Alcorn Murine Type III interferons are functionally redundant and correlate with bacterial burden during influenza/bacterial super-infection PLoS ONE, 2021-10-07;16(10):e0255309. 2021-10-07 [PMID: 34618816] (Mouse)
• S Lee, G Kalugotla, H Ingle, R Rodgers, C Wu, Y Wang, Y Li, X Yang, J Zhang, NR Borella, H Deng, L Droit, R Hill, ST Peterson, C Desai, D Lawrence, Q Lu, MT Baldridge Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota Autophagy, 2021-09-14;0(0):1-16. 2021-09-14 [PMID: 34520306] (Mouse)
• YA Ko, YH Yu, YF Wu, YC Tseng, CL Chen, KS Goh, HY Liao, TH Chen, TR Cheng, AS Yang, CH Wong, C Ma, KI Lin A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells PloS Pathogens, 2021-08-05;17(8):e1009724. 2021-08-05 [PMID: 34352041] (Mouse)
• J Xing, X Zhou, M Fang, E Zhang, LJ Minze, Z Zhang DHX15 is required to control RNA virus-induced intestinal inflammation Cell Reports, 2021-06-22;35(12):109205. 2021-06-22 [PMID: 34161762] (Mouse)
• H Ingle, E Hassan, J Gawron, B Mihi, Y Li, EA Kennedy, G Kalugotla, H Makimaa, S Lee, P Desai, KG McDonald, MS Diamond, RD Newberry, M Good, MT Baldridge Murine astrovirus tropism for goblet cells and enterocytes facilitates an IFN-&lambda response in vivo and in enteroid cultures Mucosal Immunology, 2021-03-05;0(0):. 2021-03-05 [PMID: 33674763] (Mouse)
• RR Goel, X Wang, LJ O'Neil, S Nakabo, K Hasneen, S Gupta, G Wigerblad, LP Blanco, JB Kopp, MI Morasso, SV Kotenko, ZX Yu, C Carmona-Ri, MJ Kaplan Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus Proc. Natl. Acad. Sci. U.S.A., 2020-02-24;0(0):. 2020-02-24 [PMID: 32094169] (Mouse)
• JM Veazey, TJ Chapman, TR Smyth, SE Hillman, SI Eliseeva, SN Georas Distinct roles for MDA5 and TLR3 in the acute response to inhaled double-stranded RNA PLoS ONE, 2019-05-08;14(5):e0216056. 2019-05-08 [PMID: 31067281] (Mouse)
• A Singanayag, N Glanville, JL Girkin, YM Ching, A Marcellini, JD Porter, M Toussaint, RP Walton, LJ Finney, J Aniscenko, J Zhu, MB Trujillo-T, MA Calderazzo, C Grainge, SL Loo, PC Veerati, PS Pathinayak, KS Nichol, AT Reid, PL James, R Solari, PAB Wark, DA Knight, MF Moffatt, WO Cookson, MR Edwards, P Mallia, NW Bartlett, SL Johnston Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations Nat Commun, 2018-06-08;9(1):2229. 2018-06-08 [PMID: 29884817] (Mouse)
• IE Galani, V Triantafyl, EE Eleminiado, O Koltsida, A Stavropoul, M Manioudaki, D Thanos, SE Doyle, SV Kotenko, K Thanopoulo, E Andreakos Interferon-? Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness Immunity, 2017-05-16;46(5):875-890.e6. 2017-05-16 [PMID: 28514692] (Mouse)
• Joerg Mattes TRAIL signaling is pro-inflammatory and pro-viral in a murine model of rhinovirus 1B infection Am. J. Physiol. Lung Cell Mol. Physiol., 2016-11-11;0(0):ajplung.00200. 2016-11-11 [PMID: 27836899] (Mouse)
• von Buttlar H, Siegemund S, Buttner M, Alber G Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells. PLoS ONE, 2014-08-29;9(8):e106188. 2014-08-29 [PMID: 25171368] (Mouse)
• Spann K, Loh Z, Lynch J, Ullah A, Zhang V, Baturcam E, Werder R, Khajornjiraphan N, Rudd P, Loo Y, Suhrbier A, Gale M, Upham J, Phipps S IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice. Am J Pathol, 2014-04-13;184(6):1795-806. 2014-04-13 [PMID: 24726644] (Mouse)
• Okamoto , Masaaki, Oshiumi , Hiroyuki, Azuma , Masahiro, Kato , Nobuyuki, Matsumoto , Misako, Seya , Tsukasa IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection. J Immunol, 2014-02-14;192(6):2770-7. 2014-02-14 [PMID: 24532585] (Mouse)
• Jayaraman A, Jackson D, Message S, Pearson R, Aniscenko J, Caramori G, Mallia P, Papi A, Shamji B, Edwards M, Westwick J, Hansel T, Stanciu L, Johnston S, Bartlett N IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection. Mucosal Immunol, 2014-01-29;7(5):1151-64. 2014-01-29 [PMID: 24472849] (Mouse)
• Crotta S, Davidson S, Mahlakoiv T, Desmet C, Buckwalter M, Albert M, Staeheli P, Wack A Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathog, 2013-11-21;9(11):e1003773. 2013-11-21 [PMID: 24278020] (Mouse)
• Steinberg C, Eisenacher K, Gross O, Reindl W, Schmitz F, Ruland J, Krug A The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection. Eur. J. Immunol., 2009-04-01;39(4):1007-18. 2009-04-01 [PMID: 19283778] (Mouse)