Mouse CCL8/MCP-2 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse CCL8/MCP-2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Ccl8

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL8/MCP-2 DuoSet ELISA, 15 Plate

• C-C motif chemokine 8
• CCL8
• chemokine (C-C motif) ligand 8
• HC14
• MCP2
• MCP-2
• member 8 (monocyte chemotactic protein 2)
• monocyte chemoattractant protein 2
• SCYA10
• small-inducible cytokine A8

Background

MCP-2 is a CC chemokine subfamily monocyte chemotactic protein. MCP-2 also chemoattracts activated NK cells, CD4+ and CD8+ T lymphocytes, and eosinophils and can induce histamine secretion from basophils. MCP-2 shares 62% amino acid sequence identity with MCP-1 and 58% with MCP-3.

Publications for CCL8/MCP-2 (DY790)(11)

Publications using DY790

• Sha, L;Li, J;Shen, H;Wang, Q;Meng, P;Zhang, X;Deng, Y;Zhu, W;Xu, Q; LHPP-mediated inorganic pyrophosphate hydrolysis-driven lysosomal acidification in astrocytes regulates adult neurogenesis Cell reports 2023-08-11 [PMID: 37573508] (Mouse)
• Kim, HS;Lee, HK;Kim, K;Ahn, GB;Kim, MS;Lee, TY;Son, DJ;Kim, Y;Hong, JT;Han, SB; Mesenchymal stem cells enhance CCL8 expression by podocytes in lupus-prone MRL.Faslpr mice Scientific reports 2023-08-11 [PMID: 37567910] (Transgenic Mouse)
• F Honda, H Tsuboi, Y Ono, S Abe, H Takahashi, K Ito, K Yamada, M Kawano, Y Kondo, K Asano, M Tanaka, M Malissen, B Malissen, I Matsumoto, T Sumida Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis Arthritis Research & Therapy, 2021-08-14;23(1):214. 2021-08-14 [PMID: 34391459] (Mouse)
• PLD Silva, F Lauretti-F, M Caldas de, SS Lima, AE Covarrubia, M De Franco, E Carvalho, PL Ho, RMA da Costa, EAL Martins, JB Da Silva Phagocytosis of Leptospira by leukocytes from mice with different susceptibility to leptospirosis and possible role of chemokines BMC Microbiol., 2019-01-07;19(1):4. 2019-01-07 [PMID: 30616505] (Mouse)
• Elena Farmaki Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived CCL3 Cancer Lett, 2016-12-29;0(0):. 2016-12-29 [PMID: 28041977] (Mouse)
• A CCL8 gradient drives breast cancer cell dissemination Oncogene, 2016-05-16;0(0):. 2016-05-16 [PMID: 27181207] (Mouse)
• Ottina E, Lyberg K, Sochalska M, Villunger A, Nilsson G Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis. J Immunol, 2014-12-29;194(3):1316-22. 2014-12-29 [PMID: 25548219] (Mouse)
• Dulek D, Newcomb D, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill T, Blackwell T, Moore M, Boyd K, Kolls J, Peebles R Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent manner. Infect Immun, 2014-06-23;82(9):3723-39. 2014-06-23 [PMID: 24958709] (Mouse)
• Gaffal E, Jakobs M, Glodde N, Schroder R, Kostenis E, Tuting T beta-arrestin 2 inhibits proinflammatory chemokine production and attenuates contact allergic inflammation in the skin. J Invest Dermatol, 2014-02-27;134(8):2131-7. 2014-02-27 [PMID: 24577407] (Mouse)
• Gaffal E, Cron M, Glodde N, Bald T, Kuner R, Zimmer A, Lutz B, Tuting T Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation. J Immunol, 2013-04-12;190(10):4929-36. 2013-04-12 [PMID: 23585676] (Mouse)
• Pitteri SJ, Kelly-Spratt KS, Gurley KE Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression. Cancer Res., 2011-06-08;71(15):5090-100. 2011-06-08 [PMID: 21653680] (Mouse)

FAQs for CCL8/MCP-2 (DY790). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Ccl8