MMP-19 Antibody

Product Discontinued

MMP-19 Antibody Summary

• Immunogen: Synthetic peptide corresponding to the N-terminal of human MMP19.
• Localization: Secreted
• Specificity: NB600-1518 specifically binds to MMP19 and does not cross-react with the other MMP family members (MMP1, MMP2, MMP3, MMP9, etc). The zymogen of MMP19 is found at 58 kDa and is activated to a 55 kDa form, a 45-47 kDa form, and then to a 28 kDa final active form.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MMP19
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Reactivity Notes

Not yet tested in other species.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 10mM PBS (pH 7.4) and 50% Glycerol
• Preservative: 0.1% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MMP-19 Antibody

• EC 3.4.24.-
• matrix metallopeptidase 19
• matrix metalloproteinase 18
• matrix metalloproteinase 19
• Matrix metalloproteinase RASI
• Matrix metalloproteinase-18
• matrix metalloproteinase-19
• MMP-18
• MMP18MMP-19
• MMP19
• MMP-19
• RASI
• RASI-1

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and it has a role in cellular proliferation as well as migration and adhesion to type I collagen. Multiple transcript variants encoding distict isoforms have been identified for this gene. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MMP-19 Antibody (NB600-1518)(1)

Publication using NB600-1518

• Sena P, Mariani F, Marzona L et al. Matrix metalloproteinases 15 and 19 are stromal regulators of colorectal cancer development from the early stages Int J Oncol 2012-07-01 [PMID: 22576687] (IF/IHC, WB, ICC/IF, Human)

Bioinformatics

• Gene Symbol: MMP19
• Entrez:
  • 4327(Human)