MMP-15/MT2-MMP Antibody

Product Discontinued

MMP-15/MT2-MMP Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 630-680 of Human MMP-15.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MMP15
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of MMP-15 (L646) pAb in extracts from MDA-MB-435 cells.
• Theoretical MW: 76 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MMP-15/MT2-MMP Antibody

• EC 3.4.24
• EC 3.4.24.-
• EC 3.4.24.80
• matrix metallopeptidase 15 (membrane-inserted)
• matrix metalloproteinase 15 (membrane-inserted)
• Membrane-type matrix metalloproteinase 2
• Membrane-type-2 matrix metalloproteinase
• MMP15
• MMP-15
• MT2-MMP
• MT2-MMPMT2MMP
• MTMMP2MT-MMP 2
• SMCP-2matrix metalloproteinase-15

Background

The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MMP15
• Entrez:
  • 4324(Human)