MMP-13 Antibody (VIIIA2)

Images

 
Immunohistochemistry-Paraffin: MMP-13 Antibody (VIIIA2) [NB110-5919] - Human placenta stained with MMP-13 using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of trophoblasts.

Product Details

Summary
Reactivity Hu, Mu, Rt, RbSpecies Glossary
Applications WB, IHC, IHC-P, IP
Clone
VIIIA2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.4 mg/ml

Order Details

MMP-13 Antibody (VIIIA2) Summary

Immunogen
Human recombinant collagenase-3 protein
Localization
Secreted
Specificity
Recognizes pro and acive forms of MMP 13.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MMP13
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 - 4 ug/ml
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1:12.5 - 1:25
  • Immunoprecipitation 1:25 - 1:50

Reactivity Notes

Rat reactivity reported in scientific literature (see Acta Odontol Scand. 2008). Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
10mM PBS (pH 7.4) and 0.2% BSA
Preservative
0.09% Sodium Azide
Concentration
0.4 mg/ml
Purity
Protein G purified

Alternate Names for MMP-13 Antibody (VIIIA2)

  • CLG 3
  • CLG3EC 3.4.24
  • collagenase 3
  • EC 3.4.24.-
  • EC 3.4.24.22
  • EC 3.4.24.24
  • EC 3.4.24.35
  • EC 3.4.24.65
  • EC 3.4.24.7
  • MANDP1
  • matrix metallopeptidase 13 (collagenase 3)
  • matrix metalloproteinase 13 (collagenase 3)
  • Matrix metalloproteinase-13
  • MMP13
  • MMP-13

Background

Collagenase 3 (MMP13) is a secreted 452 residue protein which is released from cells as aninactive zymogen and activated extracellularly by removal of its propeptide. MMP13 was first identified in tumor cells but has since been found in synoviocytes and normal fibroblasts stimulated by IL6 or a combination of TNF alpha and IL1. Under normal conditions, MMP13 is expressed during embryogenesis (fetal bone development) and is present only at very low levels in adult tissue. However, this enzyme is reported to be involved in the development and metastasis of breast and lung carcinomas, chondrosarcomas and osteosarcomas, head and neck carcinomas and some forms of skin cancer. Additionally, this enzyme plays an important role in degenerative bone diseases including osteoarthritis and rheumatoid arthritis. In rodents, MMP13 is thought to fill the role of MMP1, which they appear to lack.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol MMP13
Entrez
Uniprot