MMP-11 Antibody (135421) [Alexa Fluor® 594]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
135421
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 594
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

MMP-11 Antibody (135421) [Alexa Fluor® 594] Summary

Immunogen
E. coli-derived recombinant human MMP‑11
Met1-Leu488
Accession # P24347
Specificity
Detects human MMP-11 in direct ELISAs.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
MMP11
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MMP-11 Antibody (135421) [Alexa Fluor® 594]

  • EC 3.4.24
  • EC 3.4.24.-
  • EC 3.4.24.24
  • matrix metallopeptidase 11 (stromelysin 3)
  • matrix metalloproteinase 11 (stromelysin 3)
  • Matrix metalloproteinase-11
  • MMP11
  • MMP-11
  • SL-3
  • ST3
  • STMY3stromelysin 3
  • stromelysin III
  • stromelysin-3

Background

MMP-11, also called Stromelysin-3, is a metalloproteinase secreted by cells of mesenchymal origin. Human MMP-11 contains a 31 amino acid (aa) signal sequence, a 65 aa propeptide cleaved at a furin consensus sequence, and a 390 aa mature sequence with zinc metalloproteinase and hemopexin-like domains. The human 45 kDa mature MMP-11 shows 89% aa identity with mouse. An inducible low-abundance 40 kDa isoform is a constitutively active intracellular form. MMP-11 is upregulated in stromal cells near many invasive carcinomas, where it can cleave IGFBP, allowing IGF-1 to promote tumor cell growth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for MMP-11 Antibody (IC3657T) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol MMP11
Uniprot