MLK3 Antibody [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 700

MLK3 Antibody [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human MLK3
  Ala85-Gly207
  Accession # Q16584
• Specificity: Detects endogenous human MLK3 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MLK3 Antibody [Alexa Fluor® 700]

• EC 2.7.11
• EC 2.7.11.25
• MAP3K11
• MEKK11
• mitogen-activated protein kinase kinase kinase 11
• Mixed lineage kinase 3
• MLK3
• MLK3MLK-3
• PTK1
• PTK1protein-tyrosine kinase PTK1
• RHOE
• SH3 domain-containing proline-rich kinase
• SPRK
• SPRKMGC17114
• Src-homology 3 domain-containing proline-rich kinase

Background

Mixed-lineage kinases (MLKs) function as mitogen-activated protein kinase kinase kinases (MAP3Ks), activating the MAPK signaling cascades. MLK3, also known as MAP3K11 and PTK1, encodes a protein of 847 amino acids (aa) that shares an unusual leucine zipper‑basic motif found in other MLKs. Small interfering RNA experiments have indicated that MLK3 is required for both mitogen and cytokine activation of JNK1, p38 alpha , and ERK1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.