MLK3 Products

Antibodies
MLK3 Antibody
MLK3 Antibody
AF4559
Species: Hu
Applications: WB
Host: Sheep Polyclonal
MLK3 Antibody (3D11)
MLK3 Antibody (3D11)
H00004296-M02
Species: Hu
Applications: WB, ELISA, IHC-P, PLA
Host: Mouse Monoclonal
MLK3 Antibody
MLK3 Antibody
NBP1-45711
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Lysates
MLK3 Overexpression Lysate (N ...
MLK3 Overexpression Lysate (Native)
NBP2-10830
Applications: WB
Proteins
Recombinant Human MLK3 Protei ...
Recombinant Human MLK3 Protein
H00004296-Q02
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human MLK3 Protei ...
Recombinant Human MLK3 Protein
H00004296-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MLK3 RNAi
MLK3 RNAi
H00004296-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

Mixed lineage kinase-3 (MLK-3) is a mitogen-activated kinase kinase kinase that mediates stress-activating protein kinase (SAPK)/c-Jun NH2-terminal kinase activation. MLK-3 and other MLK family kinases are characterized by the presence of multiple protein-protein interaction domains including a tandem leucine/isoleucine zipper (LZs) motif. Leucine zippers are known to mediate protein dimerization raising the possibility that the tandem leucine/isoleucine zippers may function as a dimerization motif of MLK-3 (1). MLK-3 has several interesting structural features including an SH3 domain in the absence of an SH2 domain, a region containing two leucine zippers with an adjacent carboxy-terminal basic region, and a proline rich region. (2). HPK1 has been found to phosphorylate MLK-3 activation loop in vitro, and Ser281 was found to be the major phosphorylation site, indicating that HPK1 also activates MLK-3 via phosphorylation of the kinase activation loop (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 4296
Alternate Names
  • Src-homology 3 domain-containing proline-rich kinase
  • EC 2.7.11
  • Mixed lineage kinase 3
  • SH3 domain-containing proline-rich kinase
  • MEKK11
  • PTK1protein-tyrosine kinase PTK1
  • MLK3MLK-3
  • SPRKMGC17114
  • EC 2.7.11.25
  • mitogen-activated protein kinase kinase kinase 11

Research Areas for MLK3

Find related products by research area and learn more about each of the different research areas below.

Protein Kinase

PTMs for MLK3

Learn more about PTMs related to MLK3.

Phosphorylation
Methylation
Cleavage

Bioinformatics Tool for MLK3

Discover related pathways, diseases and genes to MLK3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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