MLH1 Antibody

Product Discontinued

MLH1 Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 700 and the C-terminus (residue 756) of human mutL homolog 1 using the numbering given in entry NP_000240.1 (GeneID 4292).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MLH1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Immunoprecipitation 1-4 ul
  • Western Blot 1:500-1:5000
• Control:

  MLH1 Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tris-Citrate/Phosphate (pH 7.0 - 8.0)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MLH1 Antibody

• COCA2FCC2
• DNA mismatch repair protein Mlh1
• hMLH1
• HNPCC
• HNPCC2MGC5172
• mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2)
• mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
• MutL protein homolog 1

Background

MLH1 is a DNA mismatch repair gene, mutations in MLH1 are implicated in hereditary nonpolyposis colorectal cancer (HNPCC).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MLH1 Antibody (NB100-197)(2)

Publications using NB100-197

• Jhelum P, Santos-Nogueira E, Teo W et al. Ferroptosis mediates cuprizone-induced loss of oligodendrocytes and demyelination J Neurosci 2020-10-26 [PMID: 33106352]
• Shen Y-C, Hu F-C, Jeng Y-M et al. Nuclear Overexpression of Mitotic Regulatory Proteins in Biliary Tract Cancer: Correlation with Clinicopathologic Features Patient Survival. Cancer Epidemiol Biomarkers Prev;18(2):417-423. 2009-01-01 [PMID: 19190145]

Bioinformatics

• Gene Symbol: MLH1
• Entrez:
  • 4292(Human)
• Uniprot:
  • NP_000240.1(Human)