MLH1 Products

Antibodies
MLH1 Antibody
MLH1 Antibody
NBP2-38677
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MLH1 Antibody
MLH1 Antibody
NB100-197
Species: Hu
Applications: WB, IHC, IHC-P, IP, PLA
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
Lysates
MLH1 Overexpression Lysate (N ...
MLH1 Overexpression Lysate (Native)
NBL1-13134
Applications: WB
Proteins
MLH1 Recombinant Protein
MLH1 Recombinant Protein
H00004292-P01
Species: Hu
Applications: WB, ELISA, PA
MLH1 Partial Recombinant Prot ...
MLH1 Partial Recombinant Protein
H00004292-Q01
Species: Hu
Applications: WB, ELISA, PA
MLH1 Recombinant Protein Anti ...
MLH1 Recombinant Protein Antigen
NBP2-38677PEP
Species: Hu
Applications: AC
RNAi
MLH1 RNAi
MLH1 RNAi
H00004292-R01
Species: Hu

Description

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPCC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 4292
Alternate Names
  • hMLH1
  • MutL protein homolog 1
  • DNA mismatch repair protein Mlh1
  • HNPCC
  • COCA2FCC2
  • HNPCC2MGC5172
  • mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2)
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

Research Areas for MLH1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Mismatch Repair
Tumor Suppressors

Bioinformatics Tool for MLH1

Discover related pathways, diseases and genes to MLH1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MLH1 Blog Posts

Check out the latest blog posts on MLH1.
NER, BER, HR and Other DNA Repair Pathways
A large number of antibody assays are devoted to the study of nuclear excision repair (NER) proteins. However, there are a number of other DNA repair pathways, many of which are instigated by NER and share the same proteins. DNA repair antibodies are...    Read more.
Read more MLH1 related blogs.