MLH1 Products

Description

MLH1 is a DNA mismatch repair protein. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPCC). MSHS2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Bioinformatics

Entrez	17350 Mouse 4292 Human 81685 Rat
Uniprot	AAH06850 Human NM_000249 Human NP_000240 Human NP_000240.1 Human NP_000242 Human P40692 Human
Product By Gene ID	4292
Alternate Names	COCA2FCC2 DNA mismatch repair protein Mlh1 hMLH1 HNPCC HNPCC2MGC5172 mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2) mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) MutL protein homolog 1

Research Areas for MLH1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Breast Cancer
Cancer
Cell Cycle and Replication
Checkpoint signaling
DNA Double Strand Break Repair
DNA Repair
Mismatch Repair
Tumor Suppressors

Related MLH1 Blog Posts

Check out the latest blog posts on MLH1.

NER, BER, HR and Other DNA Repair Pathways A large number of antibody assays are devoted to the study of nuclear excision repair (NER) proteins. However, there are a number of other DNA repair pathways, many of which are instigated by NER and share the same proteins. DNA repair antibodies are ...    Read more.

Read more MLH1 related blogs.