MKP-3/DUSP6 Antibody (363246) [Alexa Fluor® 594]

• Applications: WB
• Clone: 363246
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

MKP-3/DUSP6 Antibody (363246) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human MKP-3
  Ile2-Thr381
  Accession # Q16828
• Specificity: Detects endogenous human, mouse, and rat MKP-3 in Western blots. In Western blots, this antibody does not cross-react with recombinant human MKP-1 or MKP-2.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

MAP Kinase Phosphatase 3 (MKP-3), also called PYST1 and Dual Specificity Phosphatase 6 (DUSP6), dephosphorylates serine, threonine, and tyrosine residues in proteins. On Western blots, MKP-3 has an apparent molecular weight of 42 kilodaltons. It has a high degree of substrate selectivity for dephosphorylating ERK kinases over stress-related kinases such as p38 and JNK. MKP-3 is ubiquitinylated prior to degradation in the proteosome. The rate of MKP-3 degradation is enhanced by ERK-mediated phosphorylation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.