MKP-3/DUSP6 Products

Description

DUSP6 is encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	116663 Rat 1848 Human 67603 Mouse
Uniprot	AAH03143 Human NM_001946 Human NM_022652 Human NP_001937 Human NP_001937 Human NP_001937.2 Human NP_073143 Human Q16828 Human
Product By Gene ID	1848
Alternate Names	dual specificity phosphatase 6 Dual specificity protein phosphatase PYST1 EC 3.1.3.16 EC 3.1.3.48 MAP kinase phosphatase 3 Mitogen-activated protein kinase phosphatase 3 MKP-3 MKP3serine/threonine specific protein phosphatase PYST1dual specificity protein phosphatase 6

Research Areas for MKP-3/DUSP6

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Cell Cycle and Replication