Mitofusin 2 Antibody

Immunohistochemistry-Paraffin: Mitofusin 2 Antibody [NBP1-85477] - Staining of human small intestine shows strong positivity in lymphoid cells.

Immunohistochemistry-Paraffin: Mitofusin 2 Antibody [NBP1-85477] - Staining of human heart muscle shows moderate cytoplasmic positivity in myocytes.

Immunohistochemistry-Paraffin: Mitofusin 2 Antibody [NBP1-85477] - Staining of human cerebral cortex shows strong positivity in neurons.

Immunohistochemistry-Paraffin: Mitofusin 2 Antibody [NBP1-85477] - Staining of human pancreas shows very weak positivity in exocrine glandular cells as expected.

Product Discontinued

Mitofusin 2 Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: VRLIMDSLHMAAREQQVYCEEMREERQDRLKFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDDYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAITNSLQTMQQD
• Predicted Species: Mouse (93%), Rat (93%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MFN2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Reactivity Notes

Reactivity reported in scientific literature (PMID: 24013556).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Mitofusin 2 Antibody

• CMT2A
• CMT2A2
• CPRP1
• CPRP1mitochondrial assembly regulatory factor
• EC 3.6.5
• EC 3.6.5.-
• HSG
• KIAA0214hyperplasia suppressor
• MARF
• MFN2
• Mitofusin 2
• mitofusin-2
• Transmembrane GTPase MFN2

Background

MFN2 encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Mitofusin 2 Antibody (NBP1-85477)(2)

Publications using NBP1-85477

• Ramasubramanian B, Griffith C, Hanson M et al. Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO Cells 2022-02-21 [PMID: 35203393] (IF/IHC, Mouse)
• Yang JY, Yang WY. Bit-by-bit autophagic removal of parkin-labelled mitochondria. Nat Commun 2013-01-01 [PMID: 24013556]

Bioinformatics

• Gene Symbol: MFN2