MHC Class II Antibody (A6-61.3) [Allophycocyanin]

• Reactivity: Mu
• Applications: Func
• Clone: A6-61.3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

MHC Class II Antibody (A6-61.3) [Allophycocyanin] Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: This antibody was obtained from a fusion of the non-producing plasmacytoma Ag8.653 with spleen cells from ATL mice that had been immunized with ATH spleen cells.
• Specificity: This antibody is specific for mouse I-A, haplotypes H-2k, d and q. It binds to the beta-chain of mouse Ia.
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: HLA-DMA
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Radioimmunoassay
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Alternate Names for MHC Class II Antibody (A6-61.3) [Allophycocyanin]

• class II histocompatibility antigen, M alpha chain
• D6S222E
• DMA
• HLA class II histocompatibility antigen, DM alpha chain
• major histocompatibility complex, class II, DM alpha
• MHC class II antigen DMA
• Really interesting new gene 6 protein
• RING6HLADM

Background

MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HLA-DMA