Successful WB, IF, and ICC usages. WB: Detects approx. 53 and 85 kDa proteins representing overexpressed unglycosylated and glycosylated melanopsin from HEK 293 cells (does not work well on endogenously expressed protein). ICC/IF: NB100-74460 detects melanopsin from rat retinal ganglion cells (RGCs). Knockout data (PMID: 31924821).
Read Publication using NB100-74460 in the following applications:
Human reactivity reported in scientific literature (PMID: 20971788). Mouse (PMID: 22886938).
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
PBS, 1 mg/mL BSA
0.05% Sodium Azide
Immunogen affinity purified
Alternate Names for Melanopsin Antibody
Melanopsin is an opsin-like protein found in the retinal ganglion cells of mammals. Melanopsin is believed to be part of a secondary optical system that parallels that of the classic rod and cone system. This second system reports directly to the suprachiasmatic nucleus and is responsible for regulation of circadian rhythms. Melanopsin is believed to be the primary photopigment responsible for the regulation of these circadian rhythms, and Melanopsin knockout mice have been generated which demonstrate decreased capacity to entrain to light and dark cycles.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.