MEKK2 Antibody (722728) [DyLight 680]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF
• Clone: 722728
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 680

MEKK2 Antibody (722728) [DyLight 680] Summary

• Immunogen: E. coli-derived recombinant human MEKK2
  Asn42-Tyr264
  Accession # Q9Y2U5
• Specificity: Detects recombinant human MEKK2 in direct ELISA and human, mouse, rat MEKK2 in Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human MEKK1, 3, or 4 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: MAP3K2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for MEKK2 Antibody (722728) [DyLight 680]

• EC 2.7.11.25
• MAP/ERK kinase kinase 2
• MAP3K2
• MAPK/ERK kinase kinase 2
• MAPKKK2
• MEK kinase 2
• MEKK 2
• MEKK2
• MEKK2B
• mitogen-activated protein kinase kinase kinase 2

Background

MEKK2 is a Ser/Thr protein kinase belonging to the MEKK/STE11 subgroup of the MAP/ERK kinase kinase family (1). Closely related to MEKK3, MEKK2 is expressed in a multitude of tissues. MEKK2 directly phosphorylates and activates Ikappa B kinases and has been found to bind and activate protein kinase C-related kinase 2 (2). MEKK2 has also been known to activate JNK1/2, ERK1/2, p38, and ERK5 MAPK in vitro (3). MEKK2 interacting protein (Mip1) regulates MEKK2 expression (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAP3K2