MCM3AP Antibody [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB, IP (-)
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Janelia Fluor 669

MCM3AP Antibody [Janelia Fluor® 669] Summary

• Immunogen: The immunogen for this product maps to a region between residue 1 and 50 of human Germinal center-Associated Nuclear Protein using the numbering given in entry NP_003897.2 (GeneID 8888).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MCM3AP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for MCM3AP Antibody [Janelia Fluor® 669]

• 80 kDa MCM3-associated protein
• FLJ44336
• GANPFLJ45306
• human mRNA for MCM3 import factor10Protein GANP
• KIAA0572MAP80germinal center-associated nuclear protein
• Map80
• MCM3 import protein
• MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein
• MCM3 minichromosome maintenance deficient 3 associated protein
• minichromosome maintenance complex component 3 associated protein
• minichromosome maintenance deficient (S. cerevisiae) 3-associated protein
• minichromosome maintenance deficient 3-associated protein

Background

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MCM3AP