MCM3AP Products

Description

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2

Bioinformatics

Entrez	8888 Human 54387 Mouse
Uniprot	NP_003897.2 Human O60318 Human AAH13285 Human
Product By Gene ID	8888
Alternate Names	80 kDa MCM3-associated protein human mRNA for MCM3 import factor10Protein GANP minichromosome maintenance deficient 3-associated protein minichromosome maintenance deficient (S. cerevisiae) 3-associated protein MCM3 minichromosome maintenance deficient 3 associated protein MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein MCM3 import protein Map80 KIAA0572MAP80germinal center-associated nuclear protein GANPFLJ45306 FLJ44336 minichromosome maintenance complex component 3 associated protein

Diseases related to MCM3AP

Discover more about diseases related to MCM3AP.

Neoplasms
Malignant Paraganglionic Neoplasm
Cholangiocarcinoma
Aneuploidy
Malignant Neoplasms
Cell Transformation, Neoplastic
Inflammation
Monosomy
Bile Duct Neoplasms
Melanoma
Neurodegenerative Disorders
Glioma
Confusion
Hepatitis B
Anaplastic Astrocytoma
Down Syndrome
Monosomy 21
Inflammatory Response
Carcinoma
Cytomegalovirus Infections

Pathways for MCM3AP

View related products by pathway and learn more about each of the pathways below.

Dna Replication
Localization
Cell Cycle
Cell Proliferation
Transport
Cell Activation
B Cell Activation
Nuclear Export
Mitosis
Dna Repair
Regulation Of Dna Repair
Cellular Senescence
Dna Integration
Aging
Immune Response
Inflammatory Response
Cell Division
Prophase
Cell Differentiation
Mrna Processing

PTMs for MCM3AP

Learn more about PTMs related to MCM3AP.

Phosphorylation
Acetylation
Deamination

Bioinformatics Tool for MCM3AP

Discover related pathways, diseases and genes to MCM3AP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.