MCM3AP Products

Description

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2

Bioinformatics

Entrez	54387 Mouse 8888 Human
Uniprot	AAH13285 Human NP_003897.2 Human O60318 Human
Product By Gene ID	8888
Alternate Names	80 kDa MCM3-associated protein FLJ44336 GANPFLJ45306 human mRNA for MCM3 import factor10Protein GANP KIAA0572MAP80germinal center-associated nuclear protein Map80 MCM3 import protein MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein MCM3 minichromosome maintenance deficient 3 associated protein minichromosome maintenance complex component 3 associated protein minichromosome maintenance deficient (S. cerevisiae) 3-associated protein minichromosome maintenance deficient 3-associated protein