MBD1 Recombinant Protein



Product Details

Reactivity HuSpecies Glossary
Applications WB, ELISA, PA
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

MBD1 Recombinant Protein Summary

MBD1 (Human) GST-Tagged Recombinant Protein (P01)

Source: Wheat Germ (in vitro)


Packaging, Storage & Formulations

Store at -80C. Avoid freeze-thaw cycles.
50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Please see the vial label for concentration. If unlisted please contact technical services.


Application Notes
Western Blot 1:500, ELISA. This protein has not been tested for any functionality. This product may contain endotoxins and is not suitable for use with live cells.
Read Publication using H00004152-P01.


This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MBD1 Recombinant Protein

  • CXXC-type zinc finger protein 3
  • methyl-CpG binding domain protein 1 isoform PCM1
  • methyl-CpG binding domain protein 1
  • methyl-CpG-binding domain protein 1
  • Methyl-CpG-binding protein MBD1
  • Protein containing methyl-CpG-binding domain 1
  • the regulator of fibroblast growth factor 2 (FGF-2) transcription


DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. [provided by RefSeq]


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Publications for MBD1 Recombinant Protein (H00004152-P01)(1)

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for MBD1 Recombinant Protein (H00004152-P01). (Showing 1 - 1 of 1 FAQ).

  1. I am searching specifically MBD1 which will recognize and bind to methylated cytosine. Your catalog claims that your protein is for use onlu in blocking experiments but one paper listed suggests that it may be functional. Please could you comment.
    • This product is produced by a Taiwanese company called Abnova and we distribute it for them. They do not test the activity of their recombinant proteins. The proteins are produced in a cell-free wheat germ system with an N-terminal 26kDa GST-tag. Due to this expression system, in our experience, the proteins do not always undergo the same folding and post-transnational modifications they might undergo in an endogenous cell. Because of this, we do not recommend this protein for use in functional assays and do not guarantee them for this use. They are mainly intended for use in Western Blots as a positive control with their antibody.

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Contact Information

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Gene Symbol MBD1

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