MBD1 Products

Antibodies
MBD1 Antibody
MBD1 Antibody
NB100-56330
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
MBD1 Antibody
MBD1 Antibody
NBP2-59293
Species: Hu, Mu
Applications: WB, ChIP, ELISA
Host: Rabbit polyclonal
Lysates
MBD1 Overexpression Lysate (D ...
MBD1 Overexpression Lysate (Denatu...
H00004152-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human MBD1 Protei ...
Recombinant Human MBD1 Protein
H00004152-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human MBD1 Protei ...
Recombinant Human MBD1 Protein
H00004152-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MBD1 RNAi
MBD1 RNAi
H00004152-R01
Species: Hu
Applications: RNAi, RNAi SP
MBD1 RNAi
MBD1 RNAi
H00004152-R05
Species: Hu
Applications: RNAi, RNAi SP
MBD1 RNAi
MBD1 RNAi
H00004152-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 4152
Alternate Names
  • the regulator of fibroblast growth factor 2 (FGF-2) transcription
  • CXXC-type zinc finger protein 3
  • methyl-CpG-binding domain protein 1
  • Protein containing methyl-CpG-binding domain 1
  • methyl-CpG binding domain protein 1 isoform PCM1
  • Methyl-CpG-binding protein MBD1
  • PCM1CXXC3RFT
  • methyl-CpG binding domain protein 1

Research Areas for MBD1

Find related products by research area and learn more about each of the different research areas below.

Chromatin Research

Bioinformatics Tool for MBD1

Discover related pathways, diseases and genes to MBD1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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