Lysosomal Pro-X Carboxypeptidase/PRCP Antibody [Janelia Fluor® 669]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Janelia Fluor 669

Lysosomal Pro-X Carboxypeptidase/PRCP Antibody [Janelia Fluor® 669] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Lysosomal Pro‑X Carboxypeptidase/PRCP
  Met1-His496
  Accession # P42785
• Specificity: Detects human Lysosomal Pro‑X Carboxypeptidase/PRCP in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PRCP
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Lysosomal Pro-X Carboxypeptidase/PRCP Antibody [Janelia Fluor® 669]

• Angiotensinase C
• EC 3.4.16.2
• HUMPCP
• Lysosomal carboxypeptidase C
• lysosomal Pro-X carboxypeptidase
• PCPMGC2202
• PRCP
• Proline carboxypeptidase
• prolylcarboxypeptidase (angiotensinase C)
• prolylcarboxypeptidase isoform 1 preproprotein
• Prolylcarboxypeptidase

Background

PRCP is encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRCP