Lubricin/PRG4 Antibody

Product Discontinued

Lubricin/PRG4 Antibody Summary

• Immunogen: Synthetic peptide derived from Nter domain of human PRG4 protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PRG4
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry 1:50 - 1:200
  • Western Blot 1:200 - 1:1000

Packaging, Storage & Formulations

• Storage: Lyophilized antibody can be kept at 4C for up to 3 months and should be kept at -20C for long-term storage. To avoid freeze-thaw cycles, reconstituted antibody should be aliquoted before freezing for short-term storage (-20C) or for long-term storage (-80C). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
• Buffer: 0.1M Tris , 0.1M Glycine and 2% Sucrose
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A purified
• Reconstitution Instructions: Lyophilized powder, reconstituted in distilled water.

Alternate Names for Lubricin/PRG4 Antibody

• bG174L6.2 (MSF: megakaryocyte stimulating factor )
• bG174L6.2
• CACP
• FLJ32635
• HAPO
• Hemangiopoietin
• JCAP
• Lubricin
• megakaryocyte stimulating factor
• Megakaryocyte-stimulating factor
• MSF
• MSFproteoglycan 4, (megakaryocyte stimulating factor, articular superficial zoneprotein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)
• PRG4
• Proteoglycan 4
• Superficial zone proteoglycan
• SZP
• SZPHAPOarticular superficial zone protein

Background

Lubricin is a glycoprotein encoded by the PRG4 gene. It has been identified as a component of joint lubrication and synovial homeostasis by reducing friction in joints and preventing synovial cell overgrowth. It is a large, water soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRG4