LRRFIP2 Antibody

Immunohistochemistry-Paraffin: LRRFIP2 Antibody [NBP2-27199] - analysis of LRRFIP2 in formalin-fixed, paraffin-embedded human colon tissue using this antibody at 5 ug/ml.

• Reactivity: Hu, Eq, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

LRRFIP2 Antibody Summary

• Description: Novus Biologicals Rabbit LRRFIP2 Antibody (NBP2-27199) is a polyclonal antibody validated for use in IHC. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Partial synthetic peptide between amino acids 150-210 of human LRRFIP2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LRRFIP2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A purified

Alternate Names for LRRFIP2 Antibody

• DKFZp434H2035
• FLJ20248
• FLJ22683
• FLJ58304
• HUFI-2
• leucine rich repeat (in FLII) interacting protein 2
• leucine-rich repeat flightless-interacting protein 2
• LRR FLII-interacting protein 2

Background

Leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) belongs to the LRRFIP family. LRRFIP2 has multifaceted functions in innate immunity, apoptosis and development. LRRFIP2 can bind to MyD88 and positively regulate TLR activity as measured by NF-kB activity and cytokine production in macrophages. LPS stimulation also increases LRRFIP2 expression in macrophages. By interacting with Dvl, LRRFIP2 increases the cellular levels of Beta -catenin and activate Beta -catenin/LEF/TCF-dependent transcriptional activity. A dominant negative form of LRRFIP2 suppresses ectopic Wnt signaling in Xenopus embryos and partially inhibits endogenous dorsal axis formation. LRRFIP2 also interacts with Caspase-11 through Flightless-I protein and may be involved in the regulation of proinflammatory caspases by selectively modulating intracellular localization and caspase activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LRRFIP2
• Uniprot:
  • Q9Y608(Human)