LRP-1 Antibody (545503) [Unconjugated]

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Western blot shows lysates of human liver tissue. PVDF Membrane was probed with 2 µg/mL of Human LRP-1 Intracellular Domain Monoclonal Antibody (Catalog # MAB6360) followed by HRP-conjugated Anti-Mouse IgG Secondary ...read more
LRP‑1 was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Mouse Anti-Human LRP‑1 Intracellular Domain Monoclonal Antibody (Catalog # MAB6360) at 3 µg/mL for 3 hours at room ...read more
LRP‑1 was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human LRP‑1 Intracellular Domain Monoclonal Antibody (Catalog # MAB6360) at 5 µg/mL for 1 hour at room ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, ICC/IF
Clone
545503
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

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Catalog# & Formulation Size Price

LRP-1 Antibody (545503) [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human LRP-1
Gln4449-ala4544
Accession # Q07954
Specificity
Detects human LRP-1 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) LRP‑1 clusters 2, 3, or 4, rhLRP‑4, rhLRP-5, rhLRP-5 intracellular domain, rhLRP-6, rhLRP-6 intracellular domain, or rhLRPAP is observed.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
LRP1
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 2 ug/mL
  • Immunohistochemistry 5-25 ug/mL
  • Immunocytochemistry 8-25 ug/mL
Publications
Read Publication using
MAB6360 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for LRP-1 Antibody (545503) [Unconjugated]

  • A2MR
  • Alpha-2-Macroglobulin Receptor
  • APOER
  • Apolipoprotein E receptor
  • APR
  • CD91 antigen
  • CD91
  • EC 1.1.1.94
  • EC 3.4.21.9
  • IGFBP3R
  • low density lipoprotein receptor-related protein 1
  • LRP
  • LRP-1
  • LRP1A
  • prolow-density lipoprotein receptor-related protein 1
  • TbetaR-V/LRP-1/IGFBP-3 receptor
  • TGFBR5
  • type V tgf-beta receptor

Background

LRP-1 (low-density lipoprotein receptor-related protein 1) is a large type I transmembrane protein belonging to the LDL receptor superfamily. The extracellular domain of LRP-1 is organized in four clusters of ligand-binding repeats that recognizes at least 30 different ligands. The amino acid sequence of human and mouse LRP-1 cluster II share 100% identity. LRP-1 is an endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. It plays a crucial role in early embryonic development.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LRP-1 Antibody (MAB6360)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.


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Video Protocols

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Bioinformatics

Gene Symbol LRP1
Uniprot