LKB1/STK11 Antibody

Western Blot: LKB1/STK11 Antibody [NBP1-03045] - PC-3 cell lysate with LKB1 antibody at 1 ug/ml in the (A) absence or (B) presence of blocking peptide.

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-03045] - Staining of human brain, cerebellum tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Immunohistochemistry-Paraffin: LKB1/STK11 Antibody [NBP1-03045] - Staining of human skin tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Product Discontinued

LKB1/STK11 Antibody Summary

• Immunogen: A 15 aa synthetic peptide near the C-terminus of human LKB1/STK11. The immunogen is located within aa 310 - 360 of LKB1/STK11.
• Epitope: C-Terminus
• Specificity: 15 amino acid peptide from near the carboxy terminus of human LKB1/STK11
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: STK11
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Peptide affinity purified

Alternate Names for LKB1/STK11 Antibody

• EC 2.7.11.1
• LKB1 serine/threonine kinase 11 (Peutz-Jeghers syndrome)
• LKB1
• PJS polarization-related protein LKB1
• PJS
• Renal carcinoma antigen NY-REN-19
• serine/threonine kinase 11
• serine/threonine-protein kinase 11
• Serine/threonine-protein kinase LKB1
• STK11

Background

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid Serine/Threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STK11
• Entrez:
  • 6794(Human)
  • 20869(Mouse)
• Uniprot:
  • Q15831()