Leukotriene B4 R1 Antibody (203/14F11) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 203/14F11
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

Leukotriene B4 R1 Antibody (203/14F11) [Alexa Fluor™ Plus 647] Summary

• Specificity: Recognizes human Leukotriene B4 R1 (Pettersson, A. et al. (2000) Biochem. Biophys. Res. Commun. 279:520).
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Leukotriene B4 R1 Antibody (203/14F11) [Alexa Fluor™ Plus 647]

• BLT1
• chemokine receptor-like 1
• CMKRL1
• Leukotriene B4 R1
• leukotriene B4 receptor
• Leukotriene B4R1
• LTB4R
• LTB4R1
• LTBR1
• P2Y purinoceptor 7
• purinergic receptor P2Y, G-protein coupled, 7

Background

Polymorphonuclear granulocytes secrete the lipid chemotactic mediator Leukotriene B4 (LTB4) in response to inflammatory stimuli (1). Neutrophils, monocytes and lymphocytes respond to LTB4 via specific receptors localized on the cell surface (2-4). The high affinity LTB4 Receptor known as BLT1 is only expressed on leukocytes (5-7) while a second low affinity receptor BLT2 is expressed more ubiquitously (8, 9). The BLT1 and BLT2 are G-protein linked seven-transmembrane spanning receptors that share about 37-45% amino acid identity (8, 9).

1. Samuelsson, B. et al. (1987) Science 237:1171.
2. Brom, J. and W. Konig (1989) Immunology 68:479.
3. Patry, C. et al. (1996) Prostaglandins, Leukotrienes and Essential Fatty Acids 54:361.
4. Dasari, V.R. et al. (2000) Immunopharm. 48:157.
5. Pettersson, A. et al. (2000) Biochem. Biophys. Res. Comm. 279:520.
6. Yokomizo, T. et al. (1997) Nature 387:620.
7. Kato, K. et al. (2000) J. Exp. Med. 192:413.
8. Yokomizo, T. et al. (2000) J. Exp. Med. 192:421.
9. Kamohara, M. et al. (2000) J. Biol. Chem. 275:27000.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.