LATS2 Antibody [mFluor Violet 500 SE]

Product Discontinued

LATS2 Antibody [mFluor Violet 500 SE] Summary

• Immunogen: LATS, large tumor suppressor, homolog 2. (Uniprot# Q9NRM7)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LATS2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Serum
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LATS2 Antibody [mFluor Violet 500 SE]

• EC 2.7.11
• EC 2.7.11.1
• FLJ13161
• Kinase phosphorylated during mitosis protein
• KPM
• Large tumor suppressor homolog 2
• LATS (large tumor suppressor, Drosophila) homolog 2
• LATS, large tumor suppressor, homolog 2 (Drosophila)
• serine/threonine kinase KPM
• Serine/threonine-protein kinase kpm
• serine/threonine-protein kinase LATS2
• Warts-like kinase

Background

LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LATS2