LATS2 Antibody [Janelia Fluor® 549]

Product Discontinued

LATS2 Antibody [Janelia Fluor® 549] Summary

• Immunogen: LATS, large tumor suppressor, homolog 2. (Uniprot# Q9NRM7)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LATS2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Serum
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for LATS2 Antibody [Janelia Fluor® 549]

• EC 2.7.11
• EC 2.7.11.1
• FLJ13161
• Kinase phosphorylated during mitosis protein
• KPM
• Large tumor suppressor homolog 2
• LATS (large tumor suppressor, Drosophila) homolog 2
• LATS, large tumor suppressor, homolog 2 (Drosophila)
• serine/threonine kinase KPM
• Serine/threonine-protein kinase kpm
• serine/threonine-protein kinase LATS2
• Warts-like kinase

Background

LATS2 encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LATS2