Kv7.1 Recombinant Protein Antigen

• Reactivity: Hu
• Applications: AC

Kv7.1 Recombinant Protein Antigen Summary

• Description: A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human Kv7.1
  
  

  Source: E.coli

  Amino Acid Sequence: YSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQ

  Fusion Tag: N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G)

• Protein/Peptide Type: Recombinant Protein Antigen
• Gene: KCNQ1
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • Antibody Competition 10-100 molar excess
• Application Notes: This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP3-24948It is purified by IMAC chromatography, and the expected concentration is greater than 0.5 mg/ml.For current lot information, including availability, please contact our technical support team click nb-technical@bio-techne.com.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS and 1M Urea, pH 7.4.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Alternate Names for Kv7.1 Recombinant Protein Antigen

• ATFB3
• IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
• JLNS1
• KCNA8
• KCNA8FLJ26167
• KCNA9
• KCNA9Kv1.9
• KCNQ1
• kidney and cardiac voltage dependend K+ channel
• KQT-like 1
• Kv7.1
• KVLQT1
• KVLQT1ATFB1
• LQT
• LQT1
• potassium voltage-gated channel subfamily KQT member 1
• potassium voltage-gated channel, KQT-like subfamily, member 1
• RWS
• slow delayed rectifier channel subunit
• SQT2
• Voltage-gated potassium channel subunit Kv7.1
• WRS

Background

KCNQ1 encodes a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation. The gene is located in a region of chromosome 11 that contains a large number of contiguous genes that are abnormally imprinted in cancer and the Beckwith-Wiedemann syndrome. Two alternative transcripts encoding distinct isoforms have been described (from EntrezGene).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNQ1