Kv11.1 Antibody [DyLight 550]

Product Discontinued

Kv11.1 Antibody [DyLight 550] Summary

• Immunogen: Synthetic peptide made to an internal portion of human hERG (within residues 850-920). [Swiss-Prot# Q12809]
• Localization: Membrane; Multi-pass membrane protein.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNH2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
  • Western Blot
• Application Notes: This hERG antibody is useful for Immunoprecipitation, Immunocytochemistry/Immunofluorescence and Western blot, where bands are seen ~135 kDa and 95 kDa representing HERG 1a and HERG 1b respectively.

Reactivity Notes

Human, mouse, rat and canine

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Kv11.1 Antibody [DyLight 550]

• Eag homolog
• Eag-related protein 1
• ERG
• ERG1
• ERG-1
• Ether-a-go-go-related gene potassium channel 1
• ether-a-go-go-related potassium channel protein
• Ether-a-go-go-related protein 1
• HERG
• H-ERG
• hERG1
• hERG-1
• HERGhERG-1
• KCNH2
• Kv11.1
• LQT2
• potassium voltage-gated channel subfamily H member 2
• potassium voltage-gated channel, subfamily H (eag-related), member 2
• SQT1
• Voltage-gated potassium channel subunit Kv11.1

Background

Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNH2