Kir6.1 Antibody (S366-60) [DyLight 350]

• Reactivity: Hu, Mu, Rt, Ma
• Applications: ICC/IF, IHC
• Clone: S366-60
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 350

Kir6.1 Antibody (S366-60) [DyLight 350] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
• Localization: Membrane
• Specificity: Detects 45kDa.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: KCNJ8
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP2-59324. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Reactivity Notes

Use in Gerbil reported in scientific literature (PMID:31573045).

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for Kir6.1 Antibody (S366-60) [DyLight 350]

• ATP-sensitive inward rectifier potassium channel 8
• Inward rectifier K(+) channel Kir6.1
• inwardly rectifying potassium channel KIR6.1
• KCNJ8
• Kir6.1
• Potassium channel, inwardly rectifying subfamily J member 8
• potassium inwardly-rectifying channel, subfamily J, member 8
• uKATP-1

Background

The Kir6.1 (KCNJ8) gene is essential in membrane function as it encodes an inward-rectifier potassium channel protein that is 424 amino acids long and has a mass of nearly 48 kDA. Dysfunctions in the Kir6.1 gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). Research is investigating its role in various diseases such as retinitis, hypoxia, pancreatitis, myocardial infarction, spasticity, leiomyoma, acute myocardial infarction, and prinzmetal angina. The Kir6.1 gene plays a significant role in ATP sensitive potassium channels, SIDS susceptibility pathways, dopamine feedback into cAMP pathway, and the CFTR-dependent regulation of ion channels in airway epithelium. It interacts with other genes such as KCNJ2, ABCC8, ABCC9, and KCNJ11.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNJ8