Kir6.1 Antibody (S366-60) [Alexa Fluor® 405]

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Product Details

Summary
Reactivity Hu, Mu, Rt, MaSpecies Glossary
Applications ICC/IF, IHC
Clone
S366-60
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 405

Kir6.1 Antibody (S366-60) [Alexa Fluor® 405] Summary

Immunogen
Fusion protein amino acids 306-424 (Cytoplasmic C-terminus) of rat Kir6.1
Localization
Membrane
Specificity
Detects 45kDa.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KCNJ8
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Use in Gerbil reported in scientific literature (PMID:31573045).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Alternate Names for Kir6.1 Antibody (S366-60) [Alexa Fluor® 405]

  • ATP-sensitive inward rectifier potassium channel 8
  • Inward rectifier K(+) channel Kir6.1
  • inwardly rectifying potassium channel KIR6.1
  • KCNJ8
  • Kir6.1
  • Potassium channel, inwardly rectifying subfamily J member 8
  • potassium inwardly-rectifying channel, subfamily J, member 8
  • uKATP-1

Background

The Kir6.1 (KCNJ8) gene is essential in membrane function as it encodes an inward-rectifier potassium channel protein that is 424 amino acids long and has a mass of nearly 48 kDA. Dysfunctions in the Kir6.1 gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS). Research is investigating its role in various diseases such as retinitis, hypoxia, pancreatitis, myocardial infarction, spasticity, leiomyoma, acute myocardial infarction, and prinzmetal angina. The Kir6.1 gene plays a significant role in ATP sensitive potassium channels, SIDS susceptibility pathways, dopamine feedback into cAMP pathway, and the CFTR-dependent regulation of ion channels in airway epithelium. It interacts with other genes such as KCNJ2, ABCC8, ABCC9, and KCNJ11.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

FAQs for Kir6.1 Antibody (NBP2-59324AF405) (0)

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Secondary Antibodies

 

Isotype Controls

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Research Areas for Kir6.1 Antibody (NBP2-59324AF405)

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Bioinformatics

Gene Symbol KCNJ8